… quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity
in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFR wt -TK) and three …

… design and synthesis of two series of 4-pyrrylamino quinazolines as new analogs of the
epidermal growth factor receptor inhibitor … for designing and developing more potent antitumor …

… selective anticancer agents. In this study, three series of quinazoline derivatives bearing a
… -sulfonamide moiety were designed and synthesized as dual EGFR/CAIX inhibitors. All the …

… Quinazoline and quinoline derivatives are common targeted inhibitors of EGFR kinase,
and … anticancer drugs. Based on these facts, a series of heterocyclic 2,3-dihydro-[1,4]dioxino[2,3-f]…

… quinazoline derivatives as EGFR inhibitors. We designed and synthesized nine quinazolin
derivatives… In addition, the antitumor mechanism on the A431 cells was also investigated. The …

… modeling and the biological evaluation were then docked into the binding site of the …
with electron withdrawing groups (eg Cl) as in compound IVc showed higher anti-cancer …

… In order to find new and highly effective anti-tumor drugs with targeted … derivatives
containing N-phenylacetamide structure were designed, synthesized and evaluated for antitumor …

… synthesis of novel antitumor agents, much attention has been paid to design, synthesize
and evaluate a novel series of pyrazolo[3,4-d]pyrimidine derivatives based on pharmacophoric …

… Quite some of these approved anticancer agents are based on quinazoline as their main …
-4-one derivatives elicit part of their cytotoxic action by acting as EGFR inhibitors [45,46], we …

… Therefore, EGFR and HER2 tyrosine kinase inhibition assay and cancer cell proliferation
inhibition assay were used to assess the in vitro antitumor activities of designed compounds. …